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NESG statistics (data retrieved from targetdb and updated weekly) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 11,447 19,330 Expressed (E > 0) 8,596 13,241 Expressed-Soluble (ES >= 10) 5,050 6,942 Expressed-Insoluble 3,546 6,299 Purified (>= 0.5 mg yield) 2,531 3,249 HSQC spectra recorded 1,076 1,445 "Good" or "Promising" HSQC spectra 594 799 Crystal hits 776 909 Diffraction data collected 332 377 Strong-diffracting crystals (< 4 A) 289 329 X-ray crystal structures in PDB 368 NMR structures in PDB 271 Resonance assignment to BMRB 271 Distinct targets in PDB 579 Total structures in PDB 639 PSI-1 & PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 16,626 26,631 Expressed (E > 0) 11,556 16,703 Expressed-Soluble (ES >= 10) 6,773 8,909 Expressed-Insoluble 4,783 7,794 Purified (>= 0.5 mg yield) 3,622 4,424 HSQC spectra recorded 1,880 2,558 "Good" or "Promising" HSQC spectra 949 1,305 Crystal hits 995 1,154 Diffraction data collected 483 553 Strong-diffracting crystals (< 4 A) 433 498 X-ray crystal structures in PDB 475 NMR structures in PDB 355 Resonance assignment to BMRB 355 Distinct targets in PDB 755 Total structures in PDB 830 12 month structure deposition overview Target class specific statistics This plot shows Distinct Structures deposited in PDB vs time for each of the four PSI LSCs, and the CESG, a specialized center that has contributed many structures in the PSI program. "Distinct Structures" have sequences with < 98% seq_id with any other structure in the PDB on the date of deposition. Multiple crystal forms or nmr/xray pairs count only as a singleDistinct Structure. Since nmr/xray pairs have unique scientific value, the plot shows numbers of Distinct Structures deposited vs time counting a nmr and xray structure individually (dotted lines). These NMR/Xray pairs of the same protein, while not formally "Distinct Structures" have unique value for methods development projects, and provide unique insights into structure-function-dynamic relationships. This plot shows Total PDB depositions vs time for each of the four PSI LSCs, and the CESG. Total Depositions count each pdb entry; e.g. four crystal structures of a protein bound to 4 different ligands counts as 4 Total Structures. In this case NMR/Xray pairs count as 2 Total Structures. The entire PSI Program will complete ~ 5000 Total Structures by the end of Yr 10. This plot shows Distinct Structures of Human Proteins deposited in PDB vs time for each of the four PSI LSCs, and the CESG. Distinct structures have sequences with < 98% id with any other structure in the PDB on the date of deposition. This plot shows Distinct Structures of Eukaryotic Proteins deposited in PDB vs time for each of the four PSI LSCs, and the CESG. Distinct structures have sequences with < 98% id with any other structure in the PDB on the date of deposition. This plot shows Distinct Structures of Proteins determined by NMR, deposited in PDB vs time for each of the four PSI LSCs, and the CESG. Distinct structures have sequences with < 98% id with any other structure in the PDB on the date of deposition.