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NESG statistics (data retrieved from targetdb and updated weekly) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 12,317 20,833 Expressed (E > 0) 9,225 14,254 Expressed-Soluble (ES >= 10) 5,414 7,492 Expressed-Insoluble 3,811 6,762 Purified (>= 0.5 mg yield) 2,760 3,539 HSQC spectra recorded 1,173 1,547 "Good" or "Promising" HSQC spectra 651 866 Crystal hits 925 1,102 Diffraction data collected 366 425 Strong-diffracting crystals (< 4 A) 323 377 X-ray crystal structures in PDB 400 NMR structures in PDB 313 Resonance assignment to BMRB 313 Distinct targets in PDB 644 Total structures in PDB 713 PSI-1 & PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 17,521 28,134 Expressed (E > 0) 12,194 17,717 Expressed-Soluble (ES >= 10) 7,145 9,461 Expressed-Insoluble 5,049 8,256 Purified (>= 0.5 mg yield) 3,852 4,714 HSQC spectra recorded 1,979 2,660 "Good" or "Promising" HSQC spectra 1,006 1,372 Crystal hits 1,144 1,347 Diffraction data collected 517 601 Strong-diffracting crystals (< 4 A) 467 546 X-ray crystal structures in PDB 509 NMR structures in PDB 397 Resonance assignment to BMRB 397 Distinct targets in PDB 820 Total structures in PDB 906 PSI-2 assigned BIG Families NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 5,466 8,219 Expressed (E > 0) 3,976 5,616 Expressed-Soluble (ES >= 10) 2,157 2,818 Expressed-Insoluble 1,819 2,798 Purified (>= 0.5 mg yield) 1,083 1,303 HSQC spectra recorded 500 603 "Good" or "Promising" HSQC spectra 290 351 Crystal hits 327 377 Diffraction data collected 128 145 Strong-diffracting crystals (< 4 A) 105 121 X-ray crystal structures in PDB 150 NMR structures in PDB 120 Distinct targets in PDB 241 Total structures in PDB 270 Structured BIG Families 148 Structured BIG Families assigned to NESG 110 HCPIN (Human Cancer Protein Interaction Network) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 1,042 2,392 Expressed (E > 0) 776 1,594 Expressed-Soluble (ES >= 10) 406 703 Expressed-Insoluble 370 891 Purified (>= 0.5 mg yield) 204 324 HSQC spectra recorded 126 192 "Good" or "Promising" HSQC spectra 77 117 Crystal hits 70 85 Diffraction data collected 11 13 Strong-diffracting crystals (< 4 A) 11 13 X-ray crystal structures in PDB 18 NMR structures in PDB 30 Resonance assignment to BMRB 30 Distinct targets in PDB 43 Total structures in PDB 48 Human PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 2,193 3,981 Expressed (E > 0) 1,369 2,361 Expressed-Soluble (ES >= 10) 666 1,015 Expressed-Insoluble 703 1,346 Purified (>= 0.5 mg yield) 397 544 HSQC spectra recorded 187 269 "Good" or "Promising" HSQC spectra 99 149 Crystal hits 84 104 Diffraction data collected 17 24 Strong-diffracting crystals (< 4 A) 17 24 X-ray crystal structures in PDB 26 NMR structures in PDB 40 Resonance assignment to BMRB 40 Distinct targets in PDB 59 Total structures in PDB 66 Human PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 1,234 2,850 Expressed (E > 0) 876 1,814 Expressed-Soluble (ES >= 10) 453 786 Expressed-Insoluble 423 1,028 Purified (>= 0.5 mg yield) 232 367 HSQC spectra recorded 132 209 "Good" or "Promising" HSQC spectra 79 127 Crystal hits 75 91 Diffraction data collected 12 15 Strong-diffracting crystals (< 4 A) 12 15 X-ray crystal structures in PDB 20 NMR structures in PDB 37 Resonance assignment to BMRB 37 Distinct targets in PDB 51 Total structures in PDB 57 Eukaryotic PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 3,015 5,709 Expressed (E > 0) 1,670 2,883 Expressed-Soluble (ES >= 10) 807 1,283 Expressed-Insoluble 863 1,600 Purified (>= 0.5 mg yield) 448 616 HSQC spectra recorded 342 539 "Good" or "Promising" HSQC spectra 142 224 Crystal hits 89 111 Diffraction data collected 20 29 Strong-diffracting crystals (< 4 A) 20 29 X-ray crystal structures in PDB 34 NMR structures in PDB 58 Resonance assignment to BMRB 58 Distinct targets in PDB 82 Total structures in PDB 92 Eukaryotic PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 1,330 3,145 Expressed (E > 0) 935 1,928 Expressed-Soluble (ES >= 10) 489 848 Expressed-Insoluble 446 1,080 Purified (>= 0.5 mg yield) 250 387 HSQC spectra recorded 141 222 "Good" or "Promising" HSQC spectra 85 135 Crystal hits 78 94 Diffraction data collected 13 16 Strong-diffracting crystals (< 4 A) 13 16 X-ray crystal structures in PDB 22 NMR structures in PDB 49 Resonance assignment to BMRB 49 Distinct targets in PDB 64 Total structures in PDB 71 Prokaryotic PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 14,592 22,768 Expressed (E > 0) 10,582 14,945 Expressed-Soluble (ES >= 10) 6,375 8,251 Expressed-Insoluble 4,207 6,694 Purified (>= 0.5 mg yield) 3,414 4,111 HSQC spectra recorded 1,703 2,242 "Good" or "Promising" HSQC spectra 891 1,198 Crystal hits 1,057 1,238 Diffraction data collected 499 574 Strong-diffracting crystals (< 4 A) 449 519 X-ray crystal structures in PDB 475 NMR structures in PDB 339 Resonance assignment to BMRB 339 Distinct targets in PDB 738 Total structures in PDB 814 Prokaryotic PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 10,988 17,674 Expressed (E > 0) 8,291 12,317 Expressed-Soluble (ES >= 10) 4,926 6,639 Expressed-Insoluble 3,365 5,678 Purified (>= 0.5 mg yield) 2,511 3,152 HSQC spectra recorded 1,033 1,325 "Good" or "Promising" HSQC spectra 567 731 Crystal hits 847 1,008 Diffraction data collected 353 409 Strong-diffracting crystals (< 4 A) 310 361 X-ray crystal structures in PDB 378 NMR structures in PDB 264 Resonance assignment to BMRB 264 Distinct targets in PDB 580 Total structures in PDB 642 PSI-1 and PSI-2 Salmonella Protein Production Statistics (NESG Orgs: St, Sl, Sc) Production stage number of targets number of constructs Cloned 355 448 Expressed (E > 0) 298 359 Expressed-Soluble (ES >= 10) 180 210 Expressed-Insoluble 118 149 Purified (>= 0.5 mg yield) 111 124 HSQC spectra recorded 43 47 "Good" or "Promising" HSQC spectra 27 27 Crystal hits 30 33 Diffraction data collected 14 15 Strong-diffracting crystals (< 4 A) 13 14 X-ray crystal structures in PDB 10 NMR structures in PDB 11 Resonance assignment to BMRB 11 Distinct targets in PDB 17 Total structures in PDB 21 PSI-1 and PSI-2 transcription factors Production stage number of targets number of constructs Cloned 164 340 Expressed (E > 0) 115 214 Expressed-Soluble (ES >= 10) 73 131 Expressed-Insoluble 42 83 Purified (>= 0.5 mg yield) 37 55 HSQC spectra recorded 31 40 "Good" or "Promising" HSQC spectra 18 25 Crystal hits 13 13 Diffraction data collected 0 0 Strong-diffracting crystals (< 4 A) 0 0 X-ray crystal structures in PDB 2 NMR structures in PDB 2 Resonance assignment to BMRB 2 Distinct targets in PDB 4 Total structures in PDB 4 OB fold (2.40.50.140) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 329 500 Expressed (E > 0) 271 368 Expressed-Soluble (ES >= 10) 213 277 Expressed-Insoluble 58 91 Purified (>= 0.5 mg yield) 128 156 HSQC spectra recorded 70 89 "Good" or "Promising" HSQC spectra 35 45 Crystal hits 35 39 Diffraction data collected 15 16 Strong-diffracting crystals (< 4 A) 10 11 X-ray crystal structures in PDB 10 NMR structures in PDB 13 Resonance assignment to BMRB 13 Distinct targets in PDB 21 Total structures in PDB 23 OB fold (2.40.50.140) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 313 475 Expressed (E > 0) 261 355 Expressed-Soluble (ES >= 10) 206 268 Expressed-Insoluble 55 87 Purified (>= 0.5 mg yield) 123 151 HSQC spectra recorded 62 78 "Good" or "Promising" HSQC spectra 28 35 Crystal hits 35 39 Diffraction data collected 15 16 Strong-diffracting crystals (< 4 A) 10 11 X-ray crystal structures in PDB 10 NMR structures in PDB 10 Resonance assignment to BMRB 10 Distinct targets in PDB 18 Total structures in PDB 20 Oxidoreductase (3.50.50.60) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 632 726 Expressed (E > 0) 467 532 Expressed-Soluble (ES >= 10) 220 244 Expressed-Insoluble 247 288 Purified (>= 0.5 mg yield) 114 125 HSQC spectra recorded 3 4 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 34 36 Diffraction data collected 12 12 Strong-diffracting crystals (< 4 A) 12 12 X-ray crystal structures in PDB 10 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 10 Total structures in PDB 10 Oxidoreductase (3.50.50.60) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 604 693 Expressed (E > 0) 452 516 Expressed-Soluble (ES >= 10) 215 238 Expressed-Insoluble 237 278 Purified (>= 0.5 mg yield) 109 119 HSQC spectra recorded 2 2 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 33 35 Diffraction data collected 11 11 Strong-diffracting crystals (< 4 A) 11 11 X-ray crystal structures in PDB 10 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 10 Total structures in PDB 10 Ubiquitin (3.10.20.90) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 51 139 Expressed (E > 0) 30 61 Expressed-Soluble (ES >= 10) 18 31 Expressed-Insoluble 12 30 Purified (>= 0.5 mg yield) 16 21 HSQC spectra recorded 11 15 "Good" or "Promising" HSQC spectra 9 13 Crystal hits 5 7 Diffraction data collected 0 0 Strong-diffracting crystals (< 4 A) 0 0 X-ray crystal structures in PDB 0 NMR structures in PDB 11 Resonance assignment to BMRB 11 Distinct targets in PDB 11 Total structures in PDB 11 Start domain (3.30.530.20) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 196 288 Expressed (E > 0) 167 230 Expressed-Soluble (ES >= 10) 124 150 Expressed-Insoluble 43 80 Purified (>= 0.5 mg yield) 32 34 HSQC spectra recorded 24 24 "Good" or "Promising" HSQC spectra 17 17 Crystal hits 13 13 Diffraction data collected 6 6 Strong-diffracting crystals (< 4 A) 6 6 X-ray crystal structures in PDB 7 NMR structures in PDB 9 Resonance assignment to BMRB 9 Distinct targets in PDB 14 Total structures in PDB 16 Start domain (3.30.530.20) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 166 253 Expressed (E > 0) 145 208 Expressed-Soluble (ES >= 10) 105 131 Expressed-Insoluble 40 77 Purified (>= 0.5 mg yield) 21 23 HSQC spectra recorded 15 15 "Good" or "Promising" HSQC spectra 8 8 Crystal hits 9 9 Diffraction data collected 4 4 Strong-diffracting crystals (< 4 A) 4 4 X-ray crystal structures in PDB 4 NMR structures in PDB 5 Resonance assignment to BMRB 5 Distinct targets in PDB 7 Total structures in PDB 9 Tol-B (2.120.10.30) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 136 241 Expressed (E > 0) 110 180 Expressed-Soluble (ES >= 10) 56 79 Expressed-Insoluble 54 101 Purified (>= 0.5 mg yield) 31 38 HSQC spectra recorded 0 0 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 15 15 Diffraction data collected 6 6 Strong-diffracting crystals (< 4 A) 6 6 X-ray crystal structures in PDB 6 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 6 Total structures in PDB 6 Tol-B (2.120.10.30) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 133 237 Expressed (E > 0) 109 179 Expressed-Soluble (ES >= 10) 55 78 Expressed-Insoluble 54 101 Purified (>= 0.5 mg yield) 31 38 HSQC spectra recorded 0 0 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 15 15 Diffraction data collected 6 6 Strong-diffracting crystals (< 4 A) 6 6 X-ray crystal structures in PDB 6 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 6 Total structures in PDB 6 Ubiquitin E2 (3.10.110.10) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 12 21 Expressed (E > 0) 6 9 Expressed-Soluble (ES >= 10) 2 3 Expressed-Insoluble 4 6 Purified (>= 0.5 mg yield) 2 3 HSQC spectra recorded 0 0 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 0 0 Diffraction data collected 0 0 Strong-diffracting crystals (< 4 A) 0 0 X-ray crystal structures in PDB 0 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 0 Total structures in PDB 0 Ubiquitin E2 (3.10.110.10) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 4 9 Expressed (E > 0) 3 5 Expressed-Soluble (ES >= 10) 2 3 Expressed-Insoluble 1 2 Purified (>= 0.5 mg yield) 0 0 HSQC spectra recorded 0 0 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 0 0 Diffraction data collected 0 0 Strong-diffracting crystals (< 4 A) 0 0 X-ray crystal structures in PDB 0 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 0 Total structures in PDB 0 Polysaccharide Biosynthesis (3.90.550.10) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 448 523 Expressed (E > 0) 314 354 Expressed-Soluble (ES >= 10) 187 191 Expressed-Insoluble 127 163 Purified (>= 0.5 mg yield) 39 39 HSQC spectra recorded 0 0 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 9 9 Diffraction data collected 3 3 Strong-diffracting crystals (< 4 A) 2 2 X-ray crystal structures in PDB 3 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 3 Total structures in PDB 3 Polysaccharide Biosynthesis (3.90.550.10) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 442 515 Expressed (E > 0) 309 348 Expressed-Soluble (ES >= 10) 185 189 Expressed-Insoluble 124 159 Purified (>= 0.5 mg yield) 37 37 HSQC spectra recorded 0 0 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 8 8 Diffraction data collected 2 2 Strong-diffracting crystals (< 4 A) 1 1 X-ray crystal structures in PDB 2 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 2 Total structures in PDB 2 P-loop (3.40.50.300) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 844 1,158 Expressed (E > 0) 631 824 Expressed-Soluble (ES >= 10) 372 404 Expressed-Insoluble 259 420 Purified (>= 0.5 mg yield) 208 221 HSQC spectra recorded 35 38 "Good" or "Promising" HSQC spectra 9 10 Crystal hits 62 65 Diffraction data collected 26 27 Strong-diffracting crystals (< 4 A) 20 21 X-ray crystal structures in PDB 15 NMR structures in PDB 2 Resonance assignment to BMRB 2 Distinct targets in PDB 14 Total structures in PDB 17 P-loop (3.40.50.300) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 688 960 Expressed (E > 0) 534 722 Expressed-Soluble (ES >= 10) 310 342 Expressed-Insoluble 224 380 Purified (>= 0.5 mg yield) 160 173 HSQC spectra recorded 9 10 "Good" or "Promising" HSQC spectra 4 5 Crystal hits 50 53 Diffraction data collected 18 19 Strong-diffracting crystals (< 4 A) 13 14 X-ray crystal structures in PDB 13 NMR structures in PDB 2 Resonance assignment to BMRB 2 Distinct targets in PDB 12 Total structures in PDB 15 NAD(P) binding domain (3.40.50.720) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 814 990 Expressed (E > 0) 611 725 Expressed-Soluble (ES >= 10) 326 374 Expressed-Insoluble 285 351 Purified (>= 0.5 mg yield) 177 202 HSQC spectra recorded 11 12 "Good" or "Promising" HSQC spectra 1 1 Crystal hits 60 68 Diffraction data collected 29 34 Strong-diffracting crystals (< 4 A) 28 32 X-ray crystal structures in PDB 23 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 23 Total structures in PDB 23 NAD(P) binding domain (3.40.50.720) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 723 874 Expressed (E > 0) 555 663 Expressed-Soluble (ES >= 10) 289 334 Expressed-Insoluble 266 329 Purified (>= 0.5 mg yield) 153 174 HSQC spectra recorded 2 2 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 54 61 Diffraction data collected 25 29 Strong-diffracting crystals (< 4 A) 24 27 X-ray crystal structures in PDB 20 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 20 Total structures in PDB 20 Aldolase class I (3.20.20.70) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 322 465 Expressed (E > 0) 226 299 Expressed-Soluble (ES >= 10) 123 136 Expressed-Insoluble 103 163 Purified (>= 0.5 mg yield) 71 77 HSQC spectra recorded 10 11 "Good" or "Promising" HSQC spectra 2 2 Crystal hits 20 21 Diffraction data collected 11 12 Strong-diffracting crystals (< 4 A) 10 11 X-ray crystal structures in PDB 9 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 9 Total structures in PDB 9 Aldolase class I (3.20.20.70) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 175 259 Expressed (E > 0) 143 205 Expressed-Soluble (ES >= 10) 76 86 Expressed-Insoluble 67 119 Purified (>= 0.5 mg yield) 45 50 HSQC spectra recorded 2 3 "Good" or "Promising" HSQC spectra 0 0 Crystal hits 12 12 Diffraction data collected 5 5 Strong-diffracting crystals (< 4 A) 5 5 X-ray crystal structures in PDB 4 NMR structures in PDB 0 Resonance assignment to BMRB 0 Distinct targets in PDB 4 Total structures in PDB 4 Vaccinia Virus protein VP39 (3.40.50.150) PSI-1 and PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 354 558 Expressed (E > 0) 272 386 Expressed-Soluble (ES >= 10) 171 201 Expressed-Insoluble 101 185 Purified (>= 0.5 mg yield) 89 99 HSQC spectra recorded 16 16 "Good" or "Promising" HSQC spectra 6 6 Crystal hits 32 36 Diffraction data collected 18 19 Strong-diffracting crystals (< 4 A) 15 15 X-ray crystal structures in PDB 19 NMR structures in PDB 1 Resonance assignment to BMRB 1 Distinct targets in PDB 18 Total structures in PDB 20 Vaccinia Virus protein VP39 (3.40.50.150) PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 249 417 Expressed (E > 0) 203 311 Expressed-Soluble (ES >= 10) 140 169 Expressed-Insoluble 63 142 Purified (>= 0.5 mg yield) 68 77 HSQC spectra recorded 6 6 "Good" or "Promising" HSQC spectra 2 2 Crystal hits 28 32 Diffraction data collected 16 17 Strong-diffracting crystals (< 4 A) 13 13 X-ray crystal structures in PDB 15 NMR structures in PDB 1 Resonance assignment to BMRB 1 Distinct targets in PDB 14 Total structures in PDB 16 Metagenomic targets PSI-2 NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 1,056 1,801 Expressed (E > 0) 887 1,390 Expressed-Soluble (ES >= 10) 594 838 Expressed-Insoluble 293 552 Purified (>= 0.5 mg yield) 341 420 HSQC spectra recorded 111 131 "Good" or "Promising" HSQC spectra 75 87 Crystal hits 110 121 Diffraction data collected 36 37 Strong-diffracting crystals (< 4 A) 35 36 X-ray crystal structures in PDB 35 NMR structures in PDB 25 Resonance assignment to BMRB 25 Distinct targets in PDB 52 Total structures in PDB 60 MCSG salvage targets NESG Protein Production Statistics Production stage number of targets number of constructs Cloned 53 60 Expressed (E > 0) 47 49 Expressed-Soluble (ES >= 10) 34 36 Expressed-Insoluble 13 13 Purified (>= 0.5 mg yield) 28 30 HSQC spectra recorded 26 26 "Good" or "Promising" HSQC spectra 13 13 Crystal hits 7 7 Diffraction data collected 3 3 Strong-diffracting crystals (< 4 A) 3 3 X-ray crystal structures in PDB 3 NMR structures in PDB 7 Resonance assignment to BMRB 7 Distinct targets in PDB 7 Total structures in PDB 10 Year 5 BIG OPEN project (2009-03-01 - present) Production stage number of targets number of constructs Cloned 1,566 3,638 Expressed (E > 0) 1,133 2,329 Expressed-Soluble (ES >= 10) 595 1,039 Expressed-Insoluble 538 1,290 Purified (>= 0.5 mg yield) 269 413 HSQC spectra recorded 120 165 "Good" or "Promising" HSQC spectra 78 99 Crystal hits 93 119 Diffraction data collected 17 23 Strong-diffracting crystals (< 4 A) 16 22 X-ray crystal structures in PDB 26 NMR structures in PDB 31 Resonance assignment to BMRB 31 Distinct targets in PDB 51 Total structures in PDB 57