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NESG statistics NESG (complete history) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   25,924 41,201 19,048 Expression tested   24,479 38,088 17,773 Expressed (E > 0)   18,992 27,456 14,318 Expressed-Soluble (S > 0)   13,946 18,556 11,403 Expressed-Soluble (ES >= 9)   11,054 14,480 9,219 Fermented   9,440 12,040 8,259 Purification attempted   8,691 10,768 7,687 Purified (>= 0.5 mg yield)   6,493 7,807 5,726 HSQC spectra recorded   2,853 3,642 2,536 "Good" HSQC spectra   1,476 1,848 1,323 HTP crystal screening   2,845 3,370 2,573 Crystal hit   1,480 1,672 1,373 X-Ray structures   608 615 597 664 NMR structures   496 498 488 535 43 Total structures   1,061 1,078 1,034 1,199 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [activity table created 2016-04-29] NESG (PSI-1) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   5,790 7,957 5,603 Expression tested   4,698 5,929 4,569 Expressed (E > 0)   3,321 3,606 3,261 Expressed-Soluble (S > 0)   2,526 2,724 2,498 Expressed-Soluble (ES >= 9)   2,026 2,150 2,009 Fermented   2,412 3,044 2,372 Purification attempted   2,159 2,598 2,123 Purified (>= 0.5 mg yield)   1,088 1,121 1,086 HSQC spectra recorded   791 1,094 788 "Good" HSQC spectra   344 484 342 HTP crystal screening   268 268 268 Crystal hit   146 146 146 X-Ray structures   112 112 112 115 NMR structures   80 80 80 83 2 Total structures   190 190 190 198 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [activity table created 2016-04-29] NESG (PSI-2) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   15,302 21,621 11,016 Expression tested   14,490 20,236 10,334 Expressed (E > 0)   10,901 14,393 8,211 Expressed-Soluble (S > 0)   8,242 10,348 6,711 Expressed-Soluble (ES >= 9)   6,540 8,101 5,383 Fermented   4,214 4,999 3,602 Purification attempted   4,232 4,968 3,663 Purified (>= 0.5 mg yield)   3,213 3,771 2,754 HSQC spectra recorded   1,439 1,694 1,239 "Good" HSQC spectra   808 952 712 HTP crystal screening   1,932 2,227 1,728 Crystal hit   1,035 1,149 945 X-Ray structures   372 375 366 397 NMR structures   298 299 294 309 31 Total structures   639 649 622 706 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [activity table created 2016-04-30] NESG (PSI-Biology) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   6,868 13,843 4,563 Expression tested   6,404 12,873 4,169 Expressed (E > 0)   5,633 10,286 3,834 Expressed-Soluble (S > 0)   3,981 6,293 3,053 Expressed-Soluble (ES >= 9)   3,160 4,919 2,536 Fermented   3,348 4,451 2,877 Purification attempted   2,997 3,804 2,648 Purified (>= 0.5 mg yield)   2,609 3,287 2,334 HSQC spectra recorded   732 944 642 "Good" HSQC spectra   379 460 334 HTP crystal screening   736 928 679 Crystal hit   347 410 338 X-Ray structures   134 138 131 152 NMR structures   134 134 131 143 6 Total structures   262 267 256 295 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [activity table created 2016-04-30] Human proteins Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   6,879 13,870 4,274 Expression tested   6,544 13,073 3,999 Expressed (E > 0)   5,381 9,747 3,432 Expressed-Soluble (S > 0)   3,462 5,613 2,496 Expressed-Soluble (ES >= 9)   2,595 4,165 1,957 Fermented   2,665 3,590 2,159 Purification attempted   2,367 3,053 1,980 Purified (>= 0.5 mg yield)   1,991 2,559 1,697 HSQC spectra recorded   529 743 419 "Good" HSQC spectra   287 369 234 HTP crystal screening   413 587 333 Crystal hit   164 195 142 X-Ray structures   42 45 41 48 NMR structures   91 91 86 92 8 Total structures   125 130 118 140 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Eukaryotic proteins Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   8,176 17,111 5,372 Expression tested   7,567 15,493 4,831 Expressed (E > 0)   6,105 11,332 4,000 Expressed-Soluble (S > 0)   3,967 6,517 2,905 Expressed-Soluble (ES >= 9)   2,971 4,831 2,264 Fermented   3,276 4,642 2,723 Purification attempted   2,961 3,949 2,549 Purified (>= 0.5 mg yield)   2,153 2,821 1,839 HSQC spectra recorded   722 1,109 608 "Good" HSQC spectra   352 488 296 HTP crystal screening   436 615 351 Crystal hit   172 203 150 X-Ray structures   48 51 47 57 NMR structures   117 117 112 120 8 Total structures   157 162 150 177 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Prokaryotic proteins Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   17,748 24,090 13,677 Expression tested   16,912 22,596 12,943 Expressed (E > 0)   12,887 16,124 10,319 Expressed-Soluble (S > 0)   9,979 12,039 8,499 Expressed-Soluble (ES >= 9)   8,083 9,649 6,956 Fermented   6,164 7,399 5,537 Purification attempted   5,730 6,821 5,139 Purified (>= 0.5 mg yield)   4,341 4,988 3,888 HSQC spectra recorded   2,131 2,533 1,929 "Good" HSQC spectra   1,124 1,360 1,027 HTP crystal screening   2,409 2,756 2,222 Crystal hit   1,308 1,470 1,223 X-Ray structures   560 564 550 608 NMR structures   379 381 376 415 35 Total structures   904 916 884 1,023 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] CRSH Production stage NESG targets distinct constructs UniProt ids depositions cloned   176 395 142 Expression tested   176 395 142 Expressed (E > 0)   152 308 123 Expressed-Soluble (S > 0)   127 217 110 Expressed-Soluble (ES >= 9)   112 184 101 Fermented   116 167 105 Purification attempted   92 131 85 Purified (>= 0.5 mg yield)   82 114 75 HSQC spectra recorded   18 28 18 "Good" HSQC spectra   10 14 10 HTP crystal screening   60 77 57 Crystal hit   32 40 32 X-Ray structures   7 7 7 7 NMR structures   1 1 1 1 Total structures   8 8 8 8 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] PSI-2 BIG domains assigned to NESG PSI-2 BIG domains Ubiquitin-like domains Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   202 464 152 Expression tested   192 426 150 Expressed (E > 0)   153 299 128 Expressed-Soluble (S > 0)   126 218 103 Expressed-Soluble (ES >= 9)   111 183 89 Fermented   81 129 69 Purification attempted   81 120 69 Purified (>= 0.5 mg yield)   61 87 51 HSQC spectra recorded   54 76 46 "Good" HSQC spectra   37 49 31 HTP crystal screening   26 34 23 Crystal hit   12 14 12 X-Ray structures   4 4 4 5 NMR structures   19 19 18 20 2 Total structures   21 22 20 25 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Human Ubiquitin-like domains Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   86 222 62 Expression tested   76 197 60 Expressed (E > 0)   64 146 54 Expressed-Soluble (S > 0)   46 87 38 Expressed-Soluble (ES >= 9)   38 69 31 Fermented   33 54 26 Purification attempted   38 58 30 Purified (>= 0.5 mg yield)   27 42 21 HSQC spectra recorded   22 32 18 "Good" HSQC spectra   16 22 13 HTP crystal screening   9 14 7 Crystal hit   4 6 4 X-Ray structures   2 2 2 3 NMR structures   7 7 6 7 1 Total structures   8 9 7 10 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] D. Baker outreach targets Production stage NESG targets distinct constructs UniProt ids depositions cloned   416 430 394 Expression tested   381 390 370 Expressed (E > 0)   341 345 331 Expressed-Soluble (S > 0)   333 336 323 Expressed-Soluble (ES >= 9)   307 309 298 Fermented   361 363 351 Purification attempted   315 315 306 Purified (>= 0.5 mg yield)   300 300 291 HSQC spectra recorded   137 137 131 "Good" HSQC spectra   76 76 71 HTP crystal screening   251 251 243 Crystal hit   136 136 134 X-Ray structures   52 52 51 58 NMR structures   21 21 21 23 Total structures   73 73 72 81 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] HCPIN (Human Cancer Interaction Networks) Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   3,260 8,121 1,559 Expression tested   3,226 7,976 1,548 Expressed (E > 0)   2,711 5,957 1,445 Expressed-Soluble (S > 0)   1,759 3,326 1,091 Expressed-Soluble (ES >= 9)   1,367 2,511 889 Fermented   1,113 1,766 780 Purification attempted   959 1,461 695 Purified (>= 0.5 mg yield)   823 1,245 614 HSQC spectra recorded   397 579 307 "Good" HSQC spectra   231 301 187 HTP crystal screening   315 453 249 Crystal hit   131 153 110 X-Ray structures   29 29 28 30 NMR structures   71 71 68 72 6 Total structures   94 96 89 102 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Mitochondrial Proteome Partnership Production stage NESG targets distinct constructs UniProt ids depositions cloned   648 1,815 311 Expression tested   627 1,713 299 Expressed (E > 0)   505 1,182 262 Expressed-Soluble (S > 0)   351 654 216 Expressed-Soluble (ES >= 9)   290 523 190 Fermented   253 429 170 Purification attempted   194 319 137 Purified (>= 0.5 mg yield)   178 279 128 HSQC spectra recorded   57 91 44 "Good" HSQC spectra   21 33 14 HTP crystal screening   74 107 61 Crystal hit   19 29 18 X-Ray structures   3 6 3 6 NMR structures   4 4 3 4 Total structures   7 10 6 10 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Mitochondrial Proteome Partnership - nominated targets Production stage NESG targets distinct constructs UniProt ids depositions cloned   308 1,112 131 Expression tested   307 1,105 130 Expressed (E > 0)   260 766 122 Expressed-Soluble (S > 0)   201 431 117 Expressed-Soluble (ES >= 9)   171 338 108 Fermented   159 293 101 Purification attempted   115 206 78 Purified (>= 0.5 mg yield)   101 168 71 HSQC spectra recorded   29 53 22 "Good" HSQC spectra   10 22 7 HTP crystal screening   36 55 28 Crystal hit   9 13 8 X-Ray structures   2 2 2 2 NMR structures   4 4 3 4 Total structures   6 6 5 6 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Chaperone-Enabled Studies of Epigenetic Regulation Enzymes Partnership Production stage NESG targets distinct constructs UniProt ids depositions cloned   219 875 90 Expression tested   217 870 90 Expressed (E > 0)   196 749 84 Expressed-Soluble (S > 0)   128 319 70 Expressed-Soluble (ES >= 9)   99 235 59 Fermented   110 209 73 Purification attempted   84 146 62 Purified (>= 0.5 mg yield)   65 104 52 HSQC spectra recorded   19 30 16 "Good" HSQC spectra   15 22 13 HTP crystal screening   9 12 9 Crystal hit   4 4 4 X-Ray structures   1 1 1 2 NMR structures   8 8 8 8 Total structures   9 9 9 10 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Protein Homeostatis Partnership Production stage NESG targets distinct constructs UniProt ids depositions cloned   206 372 91 Expression tested   184 263 80 Expressed (E > 0)   151 208 72 Expressed-Soluble (S > 0)   119 167 64 Expressed-Soluble (ES >= 9)   90 131 50 Fermented   62 77 40 Purification attempted   56 70 37 Purified (>= 0.5 mg yield)   52 64 34 HSQC spectra recorded   10 13 6 "Good" HSQC spectra   5 6 3 HTP crystal screening   24 26 18 Crystal hit   7 9 7 X-Ray structures   0 0 0 0 NMR structures   1 1 1 1 Total structures   1 1 1 1 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-29] Human transcription factors Production stage NESG targets distinct constructs UniProt ids HUGO ids cloned   2,849 4,395 1,833 1,784 Expressed (E > 0)   2,544 3,548 1,734 1,688 Expressed-Soluble (S > 0)   1,686 2,305 1,293 1,280 Expressed-Soluble (ES >= 9)   1,171 1,633 962 957 Purified (>= 0.5 mg yield)   1,259 1,416 1,155 1,114 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30] Bet v1-like super family Production stage NESG targets distinct constructs UniProt ids depositions NMR & Xray cloned   242 335 196 Expression tested   241 331 195 Expressed (E > 0)   206 276 169 Expressed-Soluble (S > 0)   168 218 149 Expressed-Soluble (ES >= 9)   141 177 129 Fermented   117 157 109 Purification attempted   109 140 103 Purified (>= 0.5 mg yield)   102 131 98 HSQC spectra recorded   79 92 78 "Good" HSQC spectra   63 74 63 HTP crystal screening   56 68 56 Crystal hit   37 40 37 X-Ray structures   18 18 18 18 NMR structures   20 20 20 23 2 Total structures   36 36 36 41 [top statuses]     [efficiency plots]     [weekly progress]     [topBins (targets)] [attrition table created 2016-04-30]