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salicylic acid-binding protein 2 X-Ray Dan Klessig, Cornell University; Boyce Thompson Institute for Plant Research PSI-SKB highlight structure: 1Y7H Forouhar F, Yang Y, Kumar D, Chen Y, Fridman E, Park SW, Chiang Y, Acton TB, Montelione GT, Pichersky E, Klessig DF, Tong L (2005) Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity. Proc Natl Acad Sci USA, 102: 1773-8. Zhao N, Guan J, Forouhar F, Tschaplinski TJ, Cheng ZM, Tong L, Chen F (2009) Two poplar methyl salicylate esterases display comparable biochemical properties but divergent expression patterns. Phytochemistry, 70: 37-44. antibacterial peptide microcin J25 NMR Richard Ebright, Rutgers University structure: 1PP5 Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH (2003) Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot. J Amer Chem Soc, 125: 12382-3. ribosomal RNA large subunit methyltransferase A X-Ray Masayori Inouye, UMDNJ structure: 1P91 Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT (2004) Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. Proc Natl Acad Sci USA. 101: 4041-6 lipoprotein ygdR precursor NMR lipoprotein structure: 2JN0 lipoprotein ygdR precursor X-Ray lipoprotein structure: 3FIF putative HTH-type transcriptional regulator yddM X-Ray PSAM structures: 2ICP 2ICT lipoprotein yehR precursor NMR lipoprotein structure: 2JOE uncharacterized lipoprotein yajI NMR lipoprotein structure: 2JWY lipoprotein spr precursor NMR lipoprotein structure: 2K1G Aramini J, Rossi P, Huang YJ, Zhao L, Jiang M, Maglaqui M, Xiao R, Locke J, Nair R, Rost B, Acton TB, Inouye M, Montelione GT (2008) Solution NMR structure of the NIpC/P60 domain of lipoprotein Spr from Escherichia coli: structural evidence for a novel cysteine peptidase catalytic triad. Biochemistry 47: 9715-7 putative lipoprotein yceB X-Ray lipoprotein structure: 3EYR lipoprotein ymcC precursor X-Ray lipoprotein structure: 2IN5 putative outer membrane lipoprtein YiaD NMR lipoprotein structure: 2K1S thiamine biosynthesis lipoprotein apbE X-Ray lipoprotein structure: 2O18 serine phosphatase of RNA polymerase II CTD X-Ray PSAM structures: 3FDF 3FMV human BFL-1 in complex with BAK BH3 peptide X-Ray Céline Gélinas, UMDNJ structure: 3I1H CAPER RRM2 domain NMR Céline Gélinas, UMDNJ structure: 2JRS kazal-1 Domain of Human Follistatin-related protein 3 NMR PSAM structure: 2KCX homospermidine synthase X-Ray Carl Porter, Rosewell Park Cancer Institute, NY structure: 2PH5 LPPG:FO 2-phospho-L-lactate X-Ray Robert White and Ann Galinier, Virginia Tech structures: 2FFE 3C3D 3C3E 3CGW Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White R, Tong L. (2008) Molecular insights into the biosynthesis of the F420 coenzyme. J Biol Chem, 283: 11832-40. protein BQLF2 X-Ray Hongyu Deng and Ren Sun, Chinese Academy of Sciences and UCLA structures: 2H3R 2OA5 CGI121 NMR Frank Sicheri, Samuel Lunenfeld Research Institute structure: 2K8Y Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F (2008) Atomic structure of the KEOPS complex: an ancient protein kinase-contained molecular machine Mol Cell, 32: 259-75. core protein P7 X-Ray Stuart Firestein, Columbia University structure: 2Q82 DsrR IscA-like protein NMR Christiane Dahl and Frauke Grimm, Rheiniche Friedrich-Wilhelms University Bonn, Germany structure: 2K4Z de novo designed ferredoxin-like fold protein NMR David Baker, University of Washington structure: 2KL8 de novo designed Rossmann 2x2 fold protein NMR David Baker, University of Washington structure: 2KPO engineered Lipocalin FluA NMR Robert Krug, University of Texas structure: 1T0V N-terminus rat short alpha tropomysin NMR Sarah Hitchcock-DeGregori, UMDNJ structure: 1IHQ Greenfield N, Huang YJ, Palm T, Swapna GV, Monleon D, Montelione GT, Hitchcock-DeGregori SE (2001) Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomysin in an engineered chimeric protein J Mol Biol 312: 833-47. nonstructural protein NS1 X-Ray Robert Krug, University of Texas structure: 1XEQ NS1A NMR Robert Krug, University of Texas structure: 2KKZ NS1A X-Ray Robert Krug, University of Texas structure: 2RHK Yin C, Khan JA, Swapna GV, Ertekin A, Krug RM, Tong L, Montelione GT (2007) Conserved surface features form the double stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses.J Biol Chem 282: 20584-92. tropomyosin 1 alpha chain NMR Sarah Hitchcock-DeGregori, UMDNJ structures: 2G9J 1MV4 Greenfield N, Huang YJ, Swapna GV, Bhattacharya A, Rapp B, Singh A, Montelione GT, Hitchcock-DeGregori SE (2006) Solution NMR structure of the junction between tropomysin molecules: implications for actin binding and regulation J Mol Biol 364: 80-96. Greenfield N, Swapna GV, Huang YJ, Palm T, Graboski S, Montelione GT, Hitchcock-DeGregori SE (2003) The structure of the carboxyl terminus of striated alpha-tropomysin in solution reveals an unusual parallel arrangement of interacting alpha-helices Biochemistry 42: 614-9. protein yktB X-Ray MCSG structure: 2A8E protein yndB START domain NMR MCSG structure: 2KEW protein yppE NMR MCSG structure: 2HFI protein yppE X-Ray MCSG structure: 2IM8 protein yqbG NMR MCSG structures: 1XN8 1ZTS protein ysnE NMR MCSG structure: 1YX0 protein yutD NMR MCSG structure: 1KL5 protein YvbK X-Ray MCSG structure: 1YVK yxeF precursor protein NMR lipoprotein structure: 2JOZ uncharacterized protein yobA NMR lipoprotein structure: 2JQO uncharacterized lipoprotein yjhA X-Ray lipoprotein structure: 3CFU probable amino-acid ABC transporter X-Ray lipoprotein structure: 2O1M probable ABC transporter X-Ray lipoprotein structure: 2IEE iron(III)-hydroxamate-binding X-Ray lipoprotein structure: 3HXP ferrichrome-binding protein X-Ray lipoprotein structure: 3G9Q iron-uptake system-binding protein X-Ray lipoprotein structure: 2PHZ protein YcdH X-Ray lipoprotein structure: 2O1E YerB protein X-Ray lipoprotein structure: 2PSB protein yxiM precursor X-Ray lipoprotein structure: 2O14 protease synthase and sporulation X-Ray Carl Porter, Roswell Park Cancer Institute, NY structure: 1TIQ Forouhar F, Lee IS, Vujcic J, Vujcic S, Shen J, Vorobiev SM, Xiao R, Acton TB, Montelione GT, Porter CW, Tong L (2005) Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase J Biol Chem, 280: 40328-36. virulence protein STM3117 X-Ray Liang Shi, PNNL, WA structure: 3HNQ VCA0042 complexed with c-di-GMP X-Ray Andrew Camilli, Tufts MA structure: 2RDE Protein TM_1862 Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF (2007)The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO, 26: 5153-66. X-Ray Marc Fontecave and Hamid Atta, CEA, Grenoble France structure: 2QGQ Tryptophan deoxygenase X-Ray Stephen Chapman, University of Edinburgh, Scotland structure: 2NW7 Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton T, Montelione GT, Galinier A, White RH, Tong L (2008) J Biol Chem 283: 11832-40. UDP-N-acetylglucosamine tranferase NMR Barbara Imperiiali, MIT, MA structure: 2JZC Wang X, Weldeghiorghis T, Zhang G, Imperiali B, Prestegard JH (2008) Solution structure of Alg13: the sugar donor subunit of a yeast N-acetylglucosamine transferase. Structure 16:965-75.